IRE1 — Schizosaccharomyces pombe 972h-

Summary

SPAC167.01 (IRE1) in Schizosaccharomyces pombe 972h- encodes a protein with serine/threonine kinase and RNA endonuclease activities, belonging to the IRE1/2-like family and containing a protein kinase domain. It is associated with the ER membrane and the Mcs4 RR-MAPKKK complex, and is linked to the stress-activated MAPK cascade, ER stress-induced apoptosis, positive regulation of ER-phagy, cellular thermotolerance, and regulation of melanin anabolism. The gene has been associated with increased apoptosis rate, decreased entry into G0, abnormal carbon source utilization, increased thermotolerance, increased virulence, and altered cell cycle progression in M phase. Related genes in other species are linked to the IRE1 branch of the unfolded protein response.