rec25 — Schizosaccharomyces pombe 972h-

Summary

SPAC17A5.18C (rec25) on chromosome 1 of Schizosaccharomyces pombe encodes a PEP (phosphatidylethanolamine-binding) family protein. The gene is associated with multiple meiotic processes, including meiotic DNA double-strand break formation involved in reciprocal meiotic recombination, homologous recombination, gene conversion, meiotic chromosome segregation, and the second meiotic division. It is also linked to karyogamy, prophase, meiotic S phase, S phase, DNA replication, nuclear division, and chromosome division. Additional associations include regulation of CDK activity, sumoylation, nuclear import, and post-translational modification. The product localizes to chromatin, the cytosol, and the nucleus. Studies of related genes in other species link the family to linear elements.