SAS3 — Schizosaccharomyces pombe 972h-

Summary

SPAC17G8.13C (SAS3, also known as mst2) in Schizosaccharomyces pombe 972h- on chromosome 1 encodes a MYST-family histone acetyltransferase with multiple acyltransferase activities, including histone H3K4, H3K14, H4K12 acetyltransferase, crotonyltransferase, and butyryltransferase activity. The gene is associated with diverse chromatin-related processes such as heterochromatin boundary formation, telomeric silencing, DNA repair-dependent chromatin remodeling, and positive regulation of transcription elongation by RNA polymerase II. It is also linked to positive regulation of triglyceride biosynthesis, memory, osmotic response, and macroautophagy. The product localizes to the NuA3a and Piccolo histone acetyltransferase complexes, TIP60 complex, SWR-C, centric heterochromatin, and sites of DNA double-strand breaks. Studies of related genes in other species link the family to histone acetylation and, through sequence similarity, to traits including fusarium ear blight.