RAD6 — Schizosaccharomyces pombe 972h-

Summary

SPAC18B11.07C (RAD6, rhp6) on chromosome 1 of Schizosaccharomyces pombe encodes a ubiquitin-conjugating enzyme with ubiquitin conjugating enzyme activity, ubiquitin-protein transferase activity, ssDNA-dependent ATPase activity, and proteasome binding. This gene is associated with diverse cellular processes including the cellular response to UV, heterochromatin organization, recombinational repair, meiotic DNA double-strand break formation, mating type switching, and negative regulation of the SREBP signaling pathway. It is linked to the ubiquitin-dependent N-end rule pathway, error-free post-replication repair, and stress-induced protein degradation. Localization evidence connects the product to heterochromatin, telomeric regions, the cytoplasm, nucleus, and the UBR1-RAD6 and MUB1-RAD6-UBR2 complexes. Phenotypic associations include abnormal cell cycle progression, premature RNA and protein accumulation, altered pheromone sensitivity, and delayed exit from stationary phase. Studies of related genes in other species link the family to reduced virulence and stress responses.