lem2 — Schizosaccharomyces pombe 972h-

Summary

SPAC18G6.10, the lem2 gene on chromosome 1 of Schizosaccharomyces pombe 972h-, encodes a protein with a HeH/LEM domain, a MAN1 winged-helix domain, and an MSC domain. The product is associated with centromere-nuclear envelope anchor activity, heterochromatin-nuclear membrane anchor activity, centromere binding, dsDNA binding, and chromatin binding. It is linked to numerous nuclear processes including chromosome attachment to the nuclear envelope, heterochromatin organization, centromere clustering, nuclear inner membrane organization, mitotic nuclear membrane reassembly, and RNA positioning. The protein localizes to the nuclear inner membrane, nuclear envelope, centromeric core domain, subtelomere, and CENP-A-containing chromatin. Associations also include glucosylceramide anabolism, mitochondrial translation elongation, and Golgi localization.