MCM5 — Schizosaccharomyces pombe 972h-

Summary

SPAC1B2.05 (MCM5) on chromosome 1 of Schizosaccharomyces pombe encodes a member of the MCM protein family, which possesses ATP hydrolase activity (EC 3.6.4.12), DNA helicase activity, DNA replication origin binding, and H3-H4 histone carrier activity. The gene is associated with the MCM complex and localizes to the nuclear pre-replicative complex, replication forks, heterochromatin, and telomeric regions. It is linked to mitotic and premeiotic DNA replication, DNA replication licensing and initiation, double-strand break repair via break-induced replication, DNA replication-dependent chromatin assembly, and cell cycle phases including G1, S, G2, and M. Phenotypic associations include altered cell cycle progression rates, abnormal mitotic recombination, decreased mating type switching, increased sporulation, abnormal chronological lifespan, premature chromosome segregation, and meiotic arrest. Studies of related genes in other species link the family to cytokinesis abnormalities.