RRP6 — Schizosaccharomyces pombe 972h-

Summary

SPAC1F3.01 (RRP6) on chromosome 1 of Schizosaccharomyces pombe encodes a 3'-5' exoribonuclease (EC 3.1.13.-) that binds single-stranded RNA and metal ions, and is a component of the exosome (RNase complex). The protein contains an RNase H-like exonuclease domain and an HRDC domain, placing it in the Rrp6-like family. RRP6 is associated with RNA surveillance, including nuclear polyadenylation-dependent catabolic processes for CUTs, snoRNAs, snRNAs, rRNAs, tRNAs, and antisense transcripts, as well as pre-mRNA decay, histone mRNA catabolism, siRNA turnover, and exonucleolytic trimming of 5.8S rRNA. It localises to the nucleolus, nucleoplasm, cleavage bodies, Mmi1 nuclear foci, heterochromatin islands, and chromatin. Phenotypic associations link RRP6 to cell cycle progression (G1/S and G2/M transitions), decreased lifespan, delayed vegetative growth and exit from stationary phase, altered nitrogen utilisation, increased gamma ray resistance, increased virulence, decreased polyploidy, abnormal aneuploidy, and increased anaerobic growth.