FLC1 — Schizosaccharomyces pombe 972h-

Summary

SPAC1F7.03 (FLC1, pkd2) on chromosome 1 of Schizosaccharomyces pombe encodes a stretch-activated, monoatomic cation-selective calcium channel with TRP_N, TRP_C and TRP_Flc/Pkd2-like domains. The gene is associated with calcium ion import, calcineurin-mediated signaling, the MAPK cascade, cytokinesis, midbody abscission, regulation of cell shape and cell wall biogenesis, and cellular water homeostasis. It localises to the cleavage furrow, division septum, plasma membrane, Golgi and ER membranes. FLC1 is associated with turgor pressure, hyperosmotic stress resistance, ionic stress resistance, alkaline pH resistance, vegetative growth, sporulation efficiency, spore germination, biofilm formation, chitin deposition, autophagy, lifespan, and cell cycle progression through G1 phase. Related genes in other species are associated with acid sensitivity and sporulation.