RNR1 — Schizosaccharomyces pombe 972h-

Summary

SPAC1F7.05 (symbol RNR1, preferred name cdc22) on chromosome 1 of Schizosaccharomyces pombe encodes the large subunit of ribonucleoside-diphosphate reductase (EC 1.17.4.1), an enzyme with CDP reductase activity that uses thioredoxin disulfide as acceptor and binds ATP. The gene is associated with deoxyribonucleotide anabolism, dCDP and dTTP biosynthesis, and nucleotide metabolism. It is linked to mitotic and meiotic S phases, meiosis I and II, mating-type switching, DNA integrity and cell cycle checkpoints, G1 phase, M phase, chromatin silencing, and RNA anabolism. The protein localises to the cytoplasm, cytosol, and the RNR complex. Phenotypic associations include decreased vegetative growth, arrested meiosis, absent meiotic recombination, abnormal cell cycle progression through S phase and G2/M transition, arrested G1/S transition, increased entry into G0, decreased lifespan, increased gamma ray and hydrostatic pressure resistance, abnormal telomere length and mutation frequency, and absent UV resistance and micronucleophagy.