CPCC — Schizosaccharomyces pombe 972h-

Summary

SPAC20G4.03C (symbol CPCC, also known as hri1 and GCN2) on chromosome 1 of Schizosaccharomyces pombe encodes a protein serine/threonine kinase with eukaryotic translation initiation factor 2alpha kinase activity and tRNA binding capability. The gene is associated with the downregulation of translation initiation in response to various stresses, including amino acid starvation, UV exposure, and heat. It is linked to the G1/G0 cell cycle transition, positive regulation of autophagy, and downregulation of TORC1 signaling. The encoded protein localizes to the cytoplasm, cytosol, and nucleus. Phenotypic associations include altered cell cycle progression, increased virulence, abnormal spore germination, and changes in stress resistance, such as increased freeze-thaw resistance and absent UV resistance. Related genes in other species connect this gene to GCN2-mediated signaling and responses to amino acid deprivation.