NRD1 — Schizosaccharomyces pombe 972h-

Summary

SPAC222.09, also known as NRD1 or seb1 in Schizosaccharomyces pombe 972h- on chromosome 1, encodes a protein with RNA-binding domains, including an RRM and a CID domain, and is associated with RNA polymerase II C-terminal binding, lncRNA and snoRNA binding, and phase separation nucleator activity. The gene is associated with numerous RNA processing events, including lncRNA transcription, regulatory ncRNA 3'-end processing, mRNA stabilization, and cotranscriptional 3' processing of RNA polymerase II transcripts. It is linked to centromeric and chromatin silencing, sexual reproduction, nuclear import and export, cytokinesis, and responses to glucose and heat. Phenotypic associations include decreased cell cycle progression through G2/M, delayed exit from G0, increased acquired thermotolerance, decreased anaerobic and fermentative growth, increased ionic stress resistance, and altered meiotic recombination and chromosome segregation. The protein localizes to the nucleus and the Mei2 dot.