hhp2 — Schizosaccharomyces pombe 972h-

Summary

SPAC23C4.12 (hhp2) on chromosome 1 of Schizosaccharomyces pombe encodes a casein kinase I homolog (CK1_Ser-Thr_kinase) with protein serine/threonine kinase activity, protein tyrosine kinase activity, and ATP and magnesium binding. The gene is associated with regulation of DNA metabolism and repair, positive regulation of double-strand break repair, meiotic sister chromatid arm separation, homologous chromosome segregation, and meiosis II. It is linked to negative regulation of ergosterol biosynthesis, sterol homeostasis, regulation of vesicle fusion with the Golgi apparatus, ER-to-Golgi transport, endocytosis, clathrin-mediated endocytosis, filamentous growth, and circadian rhythm. Localisation evidence connects the product to the monopolin complex, spindle pole body, preribosome, vacuolar lumen, P body, and growing cell tip. Phenotypic associations include altered cell cycle progression, meiosis, sporulation, autophagy, pexophagy, peroxisomal transport and morphology, respiratory and fermentative metabolism, and vegetative growth.