SRE — Schizosaccharomyces pombe 972h-

Summary

SPAC23E2.01 (SRE, also known as fep1) on chromosome 1 of Schizosaccharomyces pombe encodes a GATA-family transcription factor with iron sensor activity, featuring a Znf_GATA domain and 2Fe-2S cluster binding. The gene product acts as a DNA-binding transcription repressor specific to RNA polymerase II, binding dsDNA and cis-regulatory regions. It is associated with cellular responses to iron and copper, iron-sulfur cluster assembly, heme and siderophore anabolism, ferrichrome anabolism, iron transport, and cellular iron ion homeostasis. The protein localises to chromatin, cytoplasm, and nucleus. It is linked to iron concentration traits. Studies of related genes in other species connect the family to reduced virulence, oxidative stress response, and polysaccharide content, though these associations are not established for the S. pombe gene itself.