MST1 — Schizosaccharomyces pombe 972h-

Summary

SPAC24C9.09 (MST1) on chromosome 1 of Schizosaccharomyces pombe encodes a threonine-tRNA ligase (EC 6.1.1.3) with threonine-tRNA ligase activity and ATP binding, belonging to the ThrRS_core and anticodon-binding domain families. The gene is associated with threonyl-tRNA aminoacylation, cytoplasmic and mitochondrial translation, and a wide range of cellular processes including chromosome condensation, chromatin silencing, DNA damage checkpoint, spindle checkpoint, homologous recombination, meiosis, mating, and fatty acid metabolism. It localises to the cytosol and mitochondria. Phenotypic associations link MST1 to increased mitochondrial rho- mutation frequency, decreased mitochondrial genome maintenance, absent respiratory growth, altered carbon and nitrogen source utilisation, increased chronological lifespan and oxidative stress resistance under some conditions, decreased vegetative growth rate, and increased heat sensitivity. The gene is also associated with chitin deposition, filamentous and invasive growth, and chemical resistance.