CIN8 — Schizosaccharomyces pombe 972h-

Summary

SPAC25G10.07C, also known as cut7 or CIN8 in Schizosaccharomyces pombe 972h- on chromosome 1, encodes a kinesin motor protein of the KIF11-like family with microtubule motor activity, ATP hydrolase activity, and microtubule binding. The gene is associated with centrosome duplication, mitotic anaphase spindle elongation, spindle breakdown, meiotic spindle assembly, and chromosome separation. It is linked to microtubule anchoring, nucleation, and cytoskeleton-dependent intracellular transport, and localizes to kinetochore, polar, and astral microtubules as well as the kinesin complex. Phenotypic associations include abnormal colony size, altered cell cycle progression in anaphase, premature metaphase-anaphase transition, delayed chromosome segregation, and abnormal nuclear fusion during mating. Related genes in other species connect the family to protein content, acid sensitivity, and oxidative stress response.