IRC5 — Schizosaccharomyces pombe 972h-

Summary

SPAC29B12.01 (IRC5, ino80) on chromosome 1 of Schizosaccharomyces pombe encodes the INO80 protein, an ATP-dependent chromatin remodeler with helicase domains (SNF2-like, DEXQc_INO80) that exhibits ATP hydrolase, DNA binding, ATP binding and histone binding activities. The gene is associated with transcription pausing by RNA polymerase II, cell quiescence, regulation of TOR signaling, DNA repair, kinetochore assembly, CENP-A-containing chromatin assembly, telomere maintenance via recombination, oxidative phosphorylation, the DNA damage checkpoint, double-strand break repair, and telomeric silencing. It localises to the Ino80 complex, centromere complex, telomeric region and chromatin. Phenotypic associations include abnormal cell cycle progression through G1/S and G2 phases, altered replicative lifespan, defective chromosome segregation, abnormal prion inheritance, and absent meiotic recombination and mating type switching. Studies of related genes in other species link the family to loss of pathogenicity and fusarium head blight.