pom1 — Schizosaccharomyces pombe 972h-

Summary

SPAC2F7.03C (pom1) on chromosome 1 of Schizosaccharomyces pombe encodes a dual-specificity protein kinase (EC 2.7.12.1) belonging to the DYRK family, with protein serine/threonine and tyrosine kinase activities, ATP binding, and phosphatidylinositol phosphate binding. This gene is associated with monopolar cell growth, asymmetric cell division, division plane positioning, contractile ring assembly, and microtubule stabilization and destabilization. It is linked to the stress-activated MAPK cascade, G2 cell size control checkpoint, regulation of mitochondrion organization, and positive regulation of mRNA splicing via the spliceosome. The protein localizes to the cell tip, lateral cell cortex, mitotic actomyosin contractile ring, mitotic spindle pole body, and cell division site. Related genes in other species are linked to increased virulence.