RUM1 — Schizosaccharomyces pombe 972h-

Summary

SPAC343.11C (RUM1, also known as msc1) in Schizosaccharomyces pombe 972h- on chromosome 1 encodes a histone demethylase with activity specific for H3K4me3 and H3K36me, and contains JmjC, JmjN, PHD-finger, and C5HC2 zinc-finger domains. The gene product is associated with chromatin binding, DNA binding, and zinc binding, and localizes to the Lid2 complex, HDAC complex, SWR-C, and heterochromatin regions including mating-type region and centric heterochromatin. RUM1 is linked to heterochromatin organization and boundary formation, RNAi-like chromatin silencing, mating-type switching, cell fate determination, cell differentiation, and sexual reproduction. It is also associated with cell cycle processes including G1, G2, and M phases, spindle assembly and checkpoint, metaphase, mitotic exit, microtubule dynamics, nuclear import, and response to nutrient conditions. Related genes in other species further connect the family to these chromatin and cell cycle functions.