CHD1 — Schizosaccharomyces pombe 972h-

Summary

SPAC3G6.01 (symbol CHD1, synonym hrp3) on chromosome 1 of Schizosaccharomyces pombe encodes a protein with chromodomain and helicase domains, and has ATP-dependent chromatin remodeller activity, including histone octamer slider and nucleosome array spacer activities, DNA translocase and helicase activities, and binding to histones, nucleosomes, chromatin, centromeres, single-stranded DNA and TATA-box binding protein. The gene is associated with nucleosome assembly, disassembly and organization, heterochromatin boundary formation, transposable element silencing, DNA double-strand break processing, transcription-coupled nucleotide excision repair, kinetochore assembly, and regulation of RNA polymerase II transcription preinitiation complex assembly. It is linked to the SHREC, CHRAC, SWI-SNF and PBAF complexes, and to CENP-A-containing and subtelomeric heterochromatin. Phenotypic associations include abnormal cell cycle progression, premature chromosome segregation, absent mating-type switching, altered telomere length, and changes in UV and X-ray resistance.