ASPB — Schizosaccharomyces pombe 972h-

Summary

SPAC4F10.11 (symbol ASPB, also known as spn1 and CDC3) on chromosome 1 of Schizosaccharomyces pombe encodes a septin-family protein with GTPase activity, structural constituent of cytoskeleton function, and phosphatidylinositol binding. The gene is associated with cytokinesis, including contractile ring assembly, midbody abscission, and septin ring disassembly, as well as actin nucleation and depolymerization, spindle breakdown, karyogamy, and meiosis II. It localizes to the bud neck septin structure, mitotic and meiotic septin complexes, and the mating projection base. Phenotypic associations include abnormal cell cycle progression (M phase, anaphase, telophase), increased aneuploidy, altered mating efficiency, increased fermentative and anaerobic growth, and decreased entry into stationary phase. Studies of related genes in other species link the family to reduced virulence.