SRS2 — Schizosaccharomyces pombe 972h-

Summary

SPAC4H3.05 (SRS2) on chromosome 1 of Schizosaccharomyces pombe encodes a UvrD-like DNA helicase with 3'-5' DNA helicase and ATP hydrolase activities. The gene is associated with multiple nuclear processes, including homologous recombination, recombinational repair, DNA damage tolerance, meiotic chromosome segregation, and rDNA maintenance. It is linked to cell cycle progression through G1/S and S phases, mitotic recombination, and sporulation efficiency. Phenotypic associations include increased thermotolerance, delayed vegetative growth, and changes in transposable element transposition and fermentative metabolism. The gene is also associated with DNA damage checkpoint function, gene conversion, and nucleotide excision repair. Studies of related genes in other species link the family to DNA repair and replication fork processing.