mes1 — Schizosaccharomyces pombe 972h-

Summary

SPAC5D6.08C (mes1) in Schizosaccharomyces pombe 972h- on chromosome 1 encodes a protein with ubiquitin ligase inhibitor activity. The gene is associated with inhibition of meiotic metaphase/anaphase transition, the meiosis I/meiosis II transition, meiotic exit, and the second meiotic division. It is also linked to broader cell cycle processes such as prophase, metaphase, anaphase, S phase, and M phase. Additional associations include nuclear division, sister chromatid cohesion, protein ubiquitination, and DNA anabolism. The product localises to both the cytosol and the nucleus.