mtr4 — Schizosaccharomyces pombe 972h-

Summary

SPAC694.02 (mtr4) on chromosome 1 of Schizosaccharomyces pombe 972h- encodes an uncharacterized helicase belonging to the SKI2 subfamily of DEAD/DEAH box helicases, with RNA helicase activity, ATP binding, nucleic acid binding, and hydrolase activity. The gene is associated with RNA surveillance, including polyadenylation-dependent ncRNA catabolic processes, siRNA catabolic processes, nuclear mRNA surveillance of spliceosomal pre-mRNA splicing, and the TRAMP-dependent tRNA surveillance pathway. It is also linked to heterochromatin island assembly, degradation of meiosis-specific transcripts, non-stop decay, 3'-5' NMD, and the endoplasmic reticulum unfolded protein response (erUPR). The encoded protein localizes to the Ski complex, NURS complex, nuclear body, heterochromatin island, nucleolus, cytoplasm, cytosol, and nucleus. Related genes in other species are linked to the TRAMP complex.