ADE6 — Schizosaccharomyces pombe 972h-

Summary

SPAC6F12.10C (ADE6) in Schizosaccharomyces pombe 972h- encodes a phosphoribosylformylglycinamidine synthase (EC 6.3.5.3) with ATP binding and metal binding activities. The gene is associated with 'de novo' IMP and purine nucleotide anabolism, as well as glutathione and pigment anabolism. It is linked to heterochromatin organization, plasmid recombination, resolution of recombination intermediates, mitotic recombination, gene conversion, cell differentiation, G2 phase, digestion, sensitization, response to amino acid, downregulation of TORC1 signaling, RNA breakdown, and PTM. The encoded protein localizes to the cytoplasm, fungal-type vacuole membrane, and Golgi complex. Phenotypic associations include increased vegetative growth, increased survival in stationary phase, increased hyperosmotic stress resistance, increased pseudohyphal growth, decreased cold sensitivity, abnormal colony color and sporulation, and altered autophagy, pexophagy, and cell cycle progression.