ASPD — Schizosaccharomyces pombe 972h-

Summary

SPAC821.06 (ASPD, spn2) on chromosome 1 of Schizosaccharomyces pombe encodes a septin family protein with a G_SEPTIN_dom and P-loop_NTPase domain, possessing GTPase activity, GTP binding, phosphatidylinositol-5-phosphate, phosphatidylinositol-4-phosphate and 1-phosphatidylinositol binding, and structural constituent of cytoskeleton and binding-bridging molecular functions. The gene is associated with numerous biological processes including cytokinesis, bipolar cell growth, cell fate determination, sex determination, G1/G0 transition, response to UV-A, ER polarization, chitin localization, septin ring disassembly, spindle breakdown, mtDNA replication, actin depolymerization, and meiotic S phase. It localizes to the septin cytoskeleton, mitotic and meiotic septin complexes, prospore and mating projection septin rings, and the ascospore wall. Phenotypic associations include abnormal cell cycle progression, delayed cytokinesis, absent cell fusion, increased mating efficiency, abnormal filamentous growth, abnormal shmoo formation, decreased endocytosis, absent vacuolar transport, decreased nucleophagy, decreased prion inheritance, increased entry into G0, and increased hydrostatic pressure resistance. Studies of related genes in other species link the family to reduced virulence and acid sensitivity.