GAP1 — Schizosaccharomyces pombe 972h-

Summary

SPAC869.11, also known as GAP1 or cat1 in Schizosaccharomyces pombe, encodes a member of the amino acid permease family (APC_YAT, AA-permease/SLC12A_dom) with L-arginine and L-lysine transporter activity. The gene is associated with basic amino acid import, including L-arginine and L-lysine transport, as well as L-leucine transport. It has been linked to cell-cell fusion, regulation of growth and cytokinesis, Ras protein signal transduction, replication fork arrest, nucleosome assembly, and cellular response to stress. Localization evidence connects the product to the plasma membrane at cell tips, medial membrane band, Golgi membrane, ER, fungal-type vacuole, and cell division sites. Phenotypic associations include altered nutrient uptake, endocytosis, sporulation, cell cycle progression, hydrostatic pressure resistance, carbon and nitrogen source utilization, and cell death rates. Studies of related genes in other species link the family to phosphate content and oxidative stress response.