LUA — Schizosaccharomyces pombe 972h-

Summary

SPAC9E9.03, also known as LUA or leu2, encodes a 3-isopropylmalate dehydratase (EC 4.2.1.33) with 3-isopropylmalate dehydratase and homoaconitate hydratase activities, and binds a 4Fe-4S cluster. This enzyme is a component of the isopropylmalate isomerase complex and localizes to the mitochondrial lumen and cytosol. The gene is associated with L-leucine and lysine biosynthesis, as well as bioluminescence, structural organization, RNA breakdown, tRNA processing, cell cycle control, homologous recombination, mating, and cell growth. Phenotypic associations include auxotrophy, decreased anaerobic and vegetative growth, abnormal colony appearance, decreased sporulation, altered chemical compound excretion and accumulation, altered heat sensitivity and toxin resistance, and changes in competitive fitness. The gene is linked to ATF1, RAV2, TFB5, and LEU2.