ARK1 — Schizosaccharomyces pombe 972h-

Summary

SPAC9G1.05 (ARK1, also known as aip1) in Schizosaccharomyces pombe encodes an uncharacterized WD repeat-containing protein that binds actin laterally and F-actin, and also binds U4 and U6 snRNA and GTP. The gene is associated with actin depolymerization and severing, centrosome duplication, chromosome segregation and biorientation, kinetochore assembly, telophase, meiosis II, TORC2 signaling, regulation of cytokinesis, and microtubule shortening. It localizes to the cortical actin cytoskeleton, actin patch, cell tip, spliceosomal complexes, and the preribosome. Phenotypic associations include decreased cytokinesis and endocytosis, delayed G2 phase progression, increased polyploidy, abnormal filamentous and pseudohyphal growth, decreased mating-type switching, and altered pheromone sensitivity and cell fusion. Studies of related genes in other species link the family to cell membrane stability and protein and phosphate content.