ENV7 — Schizosaccharomyces pombe 972h-

Summary

SPAP8A3.08 (symbol ENV7, also known as cdc4) on chromosome 1 of Schizosaccharomyces pombe 972h- encodes a protein with EF-hand calcium-binding domains and is annotated as an enzyme modulator with calcium ion binding and metal binding activities. The gene is associated with cell cycle processes including regulation of cell division, cytokinesis, contractile ring assembly, mitotic actomyosin contractile ring assembly, division septum assembly, and nuclear division, as well as spindle pole body organization, microtubule cytoskeleton organization, and sporulation. It localizes to the spindle pole body central plaque, myosin II complex, midsome, mitotic actomyosin contractile ring, cell division site, and cell tips. Phenotypic associations link ENV7 to cell cycle progression, cell size control, stress resistance, desiccation resistance, filamentous growth, telomere length, and germination rate. Studies of related genes in other species connect the family to protein kinase domains and WD40 repeats.