HH3 — Schizosaccharomyces pombe 972h-

Summary

SPBC1105.17, also known as HH3, cnp1, CSE4, and several other synonyms in Schizosaccharomyces pombe 972h- on chromosome 2, encodes a histone H3/CENP-A family protein with histone-fold domains. The product binds nucleosomal DNA and centromeres, acts as a structural constituent of chromatin, and possesses protein heterodimerization and chromatin adaptor activities. It is associated with kinetochore organization and assembly, centromere clustering and localization, mitotic metaphase chromosome alignment, heterochromatin organization and boundary formation, centromeric silencing, spindle checkpoint function, and CENP-A-containing chromatin assembly. The protein localizes to centromeric core domains, CENP-A-containing chromatin, nucleosomes, heterochromatin, and the centromere complex. Phenotypic associations include altered cell cycle progression, increased sporulation, premature meiosis, decreased hypoosmotic stress resistance, increased gamma ray resistance, and abnormal mitophagy.