HTA3 — Schizosaccharomyces pombe 972h-

Summary

SPBC11B10.10C (HTA3, also known as pht1) on chromosome 2 of Schizosaccharomyces pombe encodes a histone H2A variant, containing a Histone_H2A_C domain and a histone-fold. The product binds chromatin DNA and RNA polymerase II cis-regulatory regions, acts as a structural constituent of chromatin, and mediates protein heterodimerization and identical protein binding. HTA3 is associated with numerous chromatin-related processes including chromatin silencing, chromosome condensation, sister chromatid cohesion, homologous recombination, mitosis, anaphase, DNA damage checkpoint and response, CENP-A eviction from euchromatin, and chromatin organization. It localizes to the nucleosome, chromatin, euchromatin, and nucleus. Phenotypic associations link HTA3 to abnormal cell cycle progression, including altered rates through G1, S, and G2 phases, premature G1/S and G2/M transitions, delayed mitotic cell cycle, absent entry into G0, abnormal mitophagy and apoptosis, increased sporulation rate, abnormal mating response, and altered RNA localization.