ARK1 — Schizosaccharomyces pombe 972h-

Summary

SPBC1347.05C (ARK1, also known as SpARK1 or SpPRK1) in Schizosaccharomyces pombe 972h- encodes a DnaJ/Hsp40 family protein with a J domain and a cysteine-rich region, and is associated with heat shock protein binding, Hsp70 protein binding, ATPase activator activity, and protein sequestering activity. This gene is associated with numerous cellular processes including centrosome duplication, chromosome segregation, sister chromatid segregation, chromosome biorientation, condensation, and telophase, as well as meiosis II, microtubule shortening, and TORC2 signaling. It is linked to protein quality control, aggregate center assembly, de novo protein folding, and mitochondrial outer membrane protein import. Localization evidence places the product at the protein aggregate center, mitochondrial outer membrane, ER lumen and membrane, cell tip, and division site. Phenotypic associations include delayed cell cycle progression in G2 phase, arrested S phase, decreased cytokinesis, abnormal filamentous and pseudohyphal growth, decreased mating-type switching, increased polyploidy, and altered responses to drugs and pheromones.