MYO1 — Schizosaccharomyces pombe 972h-

Summary

SPBC146.13C (MYO1) in Schizosaccharomyces pombe 972h- encodes a myosin-I protein with an SH3 domain, a myosin head motor domain, and ATP hydrolase activity. The gene product exhibits microfilament motor activity, Arp2/3 complex binding, F-actin binding, and phospholipid binding. MYO1 is associated with cell tip growth, actin nucleation, receptor-mediated endocytosis, actin cortical patch assembly and localization, mitotic cytokinesis, membrane organization, and response to nutrient. It localizes to the myosin I complex, endocytic patch, actin cytoskeleton, hyphal tip, and medial ring. Phenotypic associations link MYO1 to abnormal bipolar budding, decreased cytokinesis rate, delayed autophagy, decreased endocytosis rate, abnormal filamentous growth, absent spore germination, sterility, and decreased cell fusion. Studies of related genes in other species connect the family to turgor pressure and potassium concentration.