POLH — Schizosaccharomyces pombe 972h-

Summary

SPBC16A3.11 (POLH, eso1) on chromosome 2 of Schizosaccharomyces pombe encodes a protein with both DNA-directed DNA polymerase activity and protein acetylase activity, belonging to the Y-family DNA polymerase and ESCO acetyltransferase families. It is associated with error-free translesion synthesis, bypass DNA synthesis, and mutagenic post-replication repair, as well as the establishment of mitotic and meiotic sister chromatid cohesion, centromere separation, telomere organization, and chromatin looping. The gene is linked to response to radiation, spindle checkpoint regulation, mitotic chromosome condensation, and tRNA gene clustering. Its product localizes to the replication fork, chromatin, and sites of double-strand breaks. Related genes in other species connect the family to sister chromatid cohesion establishment.