CREB — Schizosaccharomyces pombe 972h-

Summary

SPBC1703.12 (CREB, also known as ubp9) on chromosome 2 of Schizosaccharomyces pombe encodes a thiol-dependent deubiquitinase with metal-dependent deubiquitinase activity, belonging to the peptidase C19 and ubiquitin-specific protease families. The gene is associated with long-term memory, mRNA transcription, carbon catabolite repression, gluconeogenesis, chromatin silencing, meiosis II, and the G1 phase of the cell cycle. It is linked to defense response, osmotic response, and oxidative stress response. Localisation evidence connects the product to the cell tip, cell division site, cytosol, and nucleus. Phenotypic associations include increased X-ray resistance, decreased gamma-ray resistance, increased fermentative metabolism, decreased nutrient uptake, increased starvation resistance, decreased cold sensitivity, abnormal meiosis and chromosome segregation, and altered cell cycle progression through G2/M and G1 phases.