pat1 — Schizosaccharomyces pombe 972h-

Summary

SPBC19C2.05 (pat1) on chromosome 2 of Schizosaccharomyces pombe encodes a dual-specificity protein kinase with protein serine/threonine kinase activity, ATP binding, and phospholipid binding, belonging to the Atg1-like kinase family. This gene is associated with meiotic and mitotic cell cycle regulation, including G1/S phase transition, M phase, S phase, and G2 phase, as well as centromere clustering and separation, chromosome segregation, and the meiotic spindle checkpoint. It is linked to spermiogenesis, spermatogenesis, syngamy, and P body assembly, along with downregulation of protein import into the nucleus and carboxylic acid metabolism. The product localizes to the spindle midzone, spindle pole, spindle microtubule, interphase node, CPC complex, midsome, septin ring, and perinuclear space. Studies of related genes in other species link the family to lethality.