puc1 — Schizosaccharomyces pombe 972h-

Summary

SPBC19F5.01C (puc1) in Schizosaccharomyces pombe 972h- on chromosome 2 encodes a cyclin CLN family protein with cyclin-dependent protein serine/threonine kinase activator and regulator activity. The gene is associated with regulation of the G1/S transition of the mitotic cell cycle, the mitotic G1 cell size control checkpoint, and positive regulation of mitotic sister chromatid biorientation. It is linked to negative regulation of ascospore formation, meiotic cell cycle, and cell cycle switching from mitotic to meiotic, as well as downregulation of conjugation with cellular fusion and upregulation of filamentous growth in response to neutral pH. The product localizes to the microtubule organizing center, spindle pole bodies, CDK holoenzyme, meiotic and mitotic spindles, nucleoplasm, and telomeric chromosome regions. Studies of related genes in other species support the family's conserved roles in cell cycle control.