BCR1 — Schizosaccharomyces pombe 972h-

Summary

SPBC1D7.02C (BCR1, also known as scr1) in Schizosaccharomyces pombe encodes a C2H2 zinc-finger protein of the CreA/MIG family that acts as a DNA-binding transcription repressor specific to RNA polymerase II. The gene is associated with carbon catabolite repression, glucose homeostasis, and the regulation of carbon utilization, as well as with gluconeogenesis, the TCA cycle, electron transport chain, and the oxidative pentose pathway. It is linked to glycerol metabolism, flocculation, and the retrograde response. Phenotypic associations include altered cell cycle progression (G2 arrest, G1 increase, M-phase delay), defective meiosis, sporulation, chromosome segregation, and nuclear fusion during mating, as well as abnormal pseudohyphal growth, adhesion, chitin deposition, and autophagy. The gene is also linked to decreased fermentative and anaerobic growth, reduced UV and ionizing radiation resistance, and altered nitrogen source utilization.