TOF1 — Schizosaccharomyces pombe 972h-

Summary

SPBC216.06C (TOF1, also known as swi1) in Schizosaccharomyces pombe 972h- on chromosome 2 encodes a protein with a Timeless domain and a Timeless_N domain. The product binds Y-form DNA and double-stranded DNA. TOF1 is associated with DNA replication checkpoint, replication fork arrest at the mating-type locus, DNA imprinting, mating-type switching, meiotic chromosome segregation, sister chromatid cohesion establishment, and meiotic recombination. It localises to chromatin, the nucleus, the mitotic spindle pole body, and the FPC. Phenotypically, the gene is linked to abnormal cell fusion, altered cell cycle progression through S phase and G1/S and G2/M transitions, increased thermotolerance and gamma ray resistance, delayed vegetative growth, increased sporulation, decreased lifespan, and abnormal telomere length. Studies of related genes in other species connect it to oxidative stress response.