DIS3 — Schizosaccharomyces pombe 972h-

Summary

SPBC26H8.10 (DIS3) on chromosome 2 of Schizosaccharomyces pombe encodes a protein containing PIN, S1, and RNase II/R domains. It possesses 3'-5' exoribonuclease activity, RNA endonuclease activity, and is classified under EC 3.1.13.- and EC 3.1.26.-. DIS3 is associated with exosome-mediated RNA surveillance, exonucleolytic trimming to generate the mature 5'-end of 5.8S rRNA from the tricistronic rRNA transcript, and polyuridylation-dependent mRNA catabolic process. It is linked to regulation of G1/G0 transition, mitotic sister chromatid separation, spindle breakdown, and telophase. The gene has been associated with abnormal cell cycle progression through the G1/S phase transition, delayed exit from G0, decreased meiosis, and increased virulence. Localisation evidence places the product in the nucleolus, nucleoplasm, P-bodies, stress granules, and the cellular bud neck.