exo1 — Schizosaccharomyces pombe 972h-

Summary

SPBC29A10.05 (exo1) on chromosome 2 of Schizosaccharomyces pombe encodes a 5'-3' exonuclease with single-stranded and double-stranded DNA exonuclease activity, 5' flap endonuclease activity, and DNA binding, belonging to the XPG/Rad2 family. This gene is associated with meiotic DNA double-strand break processing, meiotic mismatch repair, strand invasion, gene conversion at the mating-type locus, and recombinational repair. It is also linked to maintenance of DNA trinucleotide repeats, replication fork arrest, Okazaki initiator RNA removal, and mitochondrial DNA metabolism. Localization evidence connects the product to the site of double-strand breaks, nucleoplasm, nucleolus, mitochondria, and mitotic spindle.