KIP3 — Schizosaccharomyces pombe 972h-

Summary

SPBC2F12.13 (KIP3, klp5) on chromosome 2 of Schizosaccharomyces pombe encodes a kinesin motor protein with microtubule plus-end polymerase activity, minus-end-directed and plus-end-directed microtubule motor activity, microtubule binding, and ATP hydrolase activity. The gene is associated with metaphase chromosome alignment, mitotic anaphase spindle elongation, spindle positioning, microtubule stabilization, plus-end specific microtubule depolymerization, meiotic spindle assembly, chromosome biorientation, and nuclear migration along microtubule. It localizes to microtubule ends, polar microtubules, the kinesin I complex, and cortical microtubule plus-ends. Phenotypic associations include delayed cell cycle progression through metaphase and anaphase, increased aneuploidy and polyploidy, decreased chromosome segregation, abnormal septum formation, and absent hyperosmotic stress resistance. Studies of related genes in other species link the family to kinetochore function.