swi3 — Schizosaccharomyces pombe 972h-

Summary

SPBC30D10.04 (swi3) in Schizosaccharomyces pombe 972h- on chromosome 2 encodes a member of the TIPIN/Csm3/Swi3 protein family. The product binds Y-form and double-stranded DNA and is associated with DNA modification, replication fork arrest at the mating-type locus, mating-type locus imprinting, and mating-type switching. It has been linked to the establishment of sister chromatid cohesion, meiotic chromosome segregation, meiotic recombination, and the DNA replication checkpoint. Additional associations include regeneration, response to MMS, and developmental processes. The protein localises to the nucleus, chromatin, the FPC complex, and mitochondria. Studies of related genes in other species connect the family to similar replication fork and cohesion functions.