SWI6 — Schizosaccharomyces pombe 972h-

Summary

SPBC336.12C (SWI6, cdc10) on chromosome 2 of Schizosaccharomyces pombe encodes a protein with an APSES-type helix-turn-helix DNA-binding domain and ankyrin repeats, classified as a SWI6-like transcription factor. The product exhibits promoter-specific chromatin binding, DNA-binding transcription repressor and activator activities for RNA polymerase II, and transcription coactivator activity. It is associated with numerous biological processes including pigment accumulation, sex determination, cell fate determination, heterochromatin organization, telomere capping, meiotic telomere clustering, astral microtubule organization, bipolar cell growth, response to UV, and G1/G0 transition. The protein localizes to the SBF and MBF complexes, chromatin, cytoplasm, cytosol, and nucleus. Studies of related genes in other species link the family to reduced virulence and oxidative stress response.