crb2 — Schizosaccharomyces pombe 972h-

Summary

SPBC342.05 (crb2) on chromosome 2 of Schizosaccharomyces pombe 972h- encodes a chromatin adaptor protein with histone reader activities, specifically recognizing histone H2A T120pho, H2A S139pho, and H4K20me2 marks, and containing BRCT domains characteristic of the TP53BP1-like family. The gene is associated with the DNA integrity checkpoint, mitotic G2 DNA damage checkpoint, and S-M checkpoint, as well as regulation of double-strand break repair via homologous recombination, recombinational repair, and strand invasion. It is linked to the response to ionizing radiation, downregulation of DNA replication, rDNA maintenance, and spindle checkpoint function. The protein localizes to chromatin, the nucleus, and sites of double-strand breaks.