ARK1 — Schizosaccharomyces pombe 972h-

Summary

SPBC36.01C (ARK1, also known as SpARK1, SpPRK1, or PRK1) on chromosome 2 of Schizosaccharomyces pombe 972h- encodes an uncharacterized transporter belonging to the major facilitator superfamily (MFS). The gene product is annotated with xenobiotic, spermidine, spermine, and transmembrane transporter activities, and is associated with peptide and fluconazole transport, as well as spermidine transport. ARK1 is associated with regulation of chromosome segregation, centrosome duplication, kinetochore assembly, sister chromatid segregation, chromosome condensation, microtubule shortening, TORC2 signaling, and meiosis II. It localizes to the fungal-type vacuole, Golgi complex, endoplasmic reticulum, and plasmalemma. The gene is associated with diverse phenotypes such as decreased endocytosis, abnormal filamentous and pseudohyphal growth, delayed cytokinesis, decreased cell fusion, and increased polyploidy. Studies of related genes in other species link the family to reduced virulence and traits including cell membrane stability and protein content.