SPBC36.05C — Schizosaccharomyces pombe 972h-

Summary

SPBC36.05C, also known as clr6, RPD3, and several other synonyms in Schizosaccharomyces pombe 972h- on chromosome 2, encodes a histone deacetylase (EC 3.5.1.98) with activity toward multiple histone H4 and H3 lysine residues, including H4-K16, H4-K12, H4-K5, H4-K8, H3-K9, and H3-K14, and possesses chromatin-binding and identical protein-binding properties. The gene is associated with heterochromatin organization and assembly, including heterochromatin islands and subtelomeric heterochromatin, as well as regulation of gene expression through epigenetic downregulation, cellular senescence, filamentous growth in response to pH, microtubule dynamics, thiamin biosynthesis, karyogamy, chromosome condensation, nitrogen utilization, demethylation, and replication fork arrest. It localizes to several complexes, including the HDA1, HDAC, Rpd3S, SHREC, SET3C, and Clr6-LE complexes, and is linked to euchromatin and rDNA heterochromatin. Phenotypic associations include abnormal cell cycle progression, mating-type switching, flocculation, sporulation, nutrient uptake, and biofilm formation, as well as acid sensitivity.