ARK1 — Schizosaccharomyces pombe 972h-

Summary

SPBC405.06 (ARK1, also known as xdj1) in Schizosaccharomyces pombe 972h- on chromosome 2 encodes a DnaJ/Hsp40 family protein with a J domain and a cysteine-rich region, possessing heat shock protein binding, ATPase activator activity, and protein sequestering activity. The gene is associated with numerous cellular processes including regulation of chromosome segregation, centrosome duplication, kinetochore assembly, sister chromatid segregation, and chromosome biorientation. It is linked to protein quality control, protein aggregate center assembly, de novo protein folding, and TORC2 signaling. Localization evidence connects the product to the protein aggregate center, mitochondrial outer membrane, ER, and cell division sites. Phenotypic associations include delayed cytokinesis, decreased endocytosis, abnormal filamentous growth, altered mating-type switching, increased polyploidy, and decreased necrotic cell death. Studies of related genes in other species link the family to cell membrane stability and protein content.