BD — Schizosaccharomyces pombe 972h-

Summary

SPBC428.16C, also known as BD or SpBD, encodes the small GTPase rhb1, a member of the Ras-type family with GDP/GTP binding and GTPase activity, and is associated with protein ser/thr kinase activator activity. In Schizosaccharomyces pombe, this gene is associated with Ras protein signal transduction, TORC1 and TORC2 signaling, response to glucose and metformin, regulation of cytoskeleton organization, cell-cell fusion, karyogamy, amino acid import, and both positive and negative regulation of asexual sporulation. It localizes to the plasma membrane, cytosol, and nucleus. Phenotypic associations include altered vacuolar transport, bipolar budding, redox state, mating-type switching, entry into stationary phase, osmotic and oxidative stress resistance, nuclear export, pheromone production, protein transport, cell cycle progression, prion inheritance, flocculation, and transposable element transposition. Studies of related genes in other species link the family to reduced virulence and protein content.