SAD1 — Schizosaccharomyces pombe 972h-

Summary

SPBC577.07, also known as SAD1 or ubp10, encodes a thiol-dependent deubiquitinase with zinc-binding capability, belonging to the ubiquitin carboxyl-terminal hydrolase family. In Schizosaccharomyces pombe, this gene is associated with mitotic nuclear envelope breakdown, chromosome attachment to the nuclear envelope, astral microtubule organization, meiotic telomere clustering, centromere clustering, SPB organization, and karyogamy. The protein localizes to the nucleus and the U4/U6.U5 snRNP complex. Phenotypic associations link SAD1 to cell cycle arrest, decreased resistance to X-ray and gamma radiation, increased desiccation resistance, abnormal spindle morphology, decreased spore germination, and altered cell size and shape. Studies of related genes in other species suggest the family may also be connected to telomere length regulation.